Transcription Regulation

  Introduction R-loops are three-stranded RNA:DNA loops  when the nascently transcribed RNA anneals with the template DNA strand and displaces the non-template DNA as unpaired single strand. Besides nascent mRNAs, long non-coding RNAs (lncRNAs) may also create and form R-loops.  Mounting evidences now support cells can harness R-loops to regulate gene expression in ways including epigenetic […]